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pentobarbital will reduce the level or effect of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the extent or outcome of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Decreased AUC of tramadol and also the Energetic metabolite (O-desmet

pentobarbital will lessen the extent or outcome of fludrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Phenobarbital has the lowest lipid solubility, lowest plasma binding, cheapest Mind protein binding, the longest hold off in onset of activity, along with the longest duration of motion. At the alternative